How to dose NAD+ shots

Any NAD injection dosage you find online is a study dose or one clinic's protocol. Neither has been proven for you. FDA has not approved any NAD+ drug, and it lists NAD as a bulk substance still under evaluation for compounding. A 2026 review of IV NAD+ concluded that optimal dosing cannot currently be established.

Here are the doses published studies have used. They are study doses, not recommendations, and most went into a vein rather than under the skin.

The spread runs from 10 mg to 750 mg in very different groups, and none of these studies tested a long-term schedule of NAD+ shots. The steps below help you follow a prescription well rather than build one, including how to inject NAD+ once the dose is set.

1. 01

   Step 1: Start with the dose your clinician prescribes

   Your dose and how often to inject it come from your prescription. Your clinician sets it from your health history, so do not start from a dosing chart, a friend's protocol or the table above. Check the strength on your medication label against your written dose before every draw. If your syringe is marked in units rather than milliliters, ask your clinician or pharmacist to write the dose in units too.

   FDA has linked dosing errors with other compounded vials to confusion between milliliters, milligrams and units. If the numbers do not agree, stop and ask.

2. 02

   Step 2: Choose subcutaneous or intramuscular injection

   A subcutaneous shot goes into the fatty tissue just under the skin. An intramuscular shot goes into a muscle. The route is part of your prescription, not a choice made on the day. Harbor's NAD+ program uses the subcutaneous route, injected at home. For an NAD subcutaneous injection, MedlinePlus lists the belly at least 2 inches from the belly button, the outer upper thigh and the back or side of the upper arm. Wash your hands, clean the skin with an alcohol pad and let it dry, pinch about an inch of skin and fat, insert the needle at 90 degrees (45 degrees if there is little fat), release the skin, push the plunger, then put the needle straight into your sharps container. Place each new shot at least 1 inch from the last one.

   No published trial shows one route working better than another.

3. 03

   Step 3: Set how often you inject

   There is no established NAD injection frequency. The studies used short IV courses, so none describes how often to take shots over months. Your clinician prescribes the frequency along with the dose. Once it is set, keep it fixed. Use the same days and time, with a phone reminder.

4. 04

   Step 4: Track energy & sleep each week

   Keep a short weekly log: the date, the dose, the site, your usual hours of sleep and a one-to-five rating for energy. It gives you and your clinician something concrete to read together. A 2026 systematic review found no outcome trials of IV or intramuscular NAD+ for wellness, so the log is a record for your follow-up rather than proof the shots work. Tiredness has many causes, and some need a different workup.

5. 05

   Step 5: Review the plan at follow-up

   Bring the log to each check-in, where your clinician decides whether to keep, change or stop the plan. Never adjust the dose or schedule on your own between visits. Mention any NAD+ precursors you take, such as nicotinamide riboside or nicotinamide mononucleotide, and any IV NAD+ you have had elsewhere.

Most NAD+ dosage problems start with treating someone else's number as your own. Rule these out early.

• Copying a dose chart. Online charts mix study doses, IV protocols and clinic preferences, and only your prescription applies to you.
• Treating an IV dose as a shot dose. The 500 mg and 750 mg figures in the studies were infusions given over hours, and they do not translate into a shot.
• Mixing up milligrams, milliliters and units. Check the label against the written dose every time.
• Doubling the next shot after a missed one. Ask your clinician what to do instead.
• Buying injectable NAD+ from an unknown source. Use only what your prescription and a licensed pharmacy supply. FDA has warned that some compounders used food-grade NAD+ to make IV products, and food-grade ingredients are not suitable for sterile drugs without appropriate processing.
• Skipping the basics. Shots do not replace daily habits, so learn how to raise NAD+ levels with food, exercise and steady sleep first.

Harbor NAD+ shots start with a 90-second online quiz. A board-certified physician licensed in your state reviews your health history and goals, and if it is not the right fit, you are not charged. If it is, your medication is compounded by a licensed U.S. pharmacy and shipped free. Compounded NAD+ is not FDA approved.

From there, NAD shots are a self-administered subcutaneous injection at home, on a schedule your clinician sets. Licensed clinicians are available 24/7, and regular check-ins let your clinician adjust the program as needed.

The program starts from $99/mo, a flat monthly price that does not rise as your dose changes, with no insurance required. The program aims to support your NAD+ levels under clinician guidance, without promising a specific result.